After treatment, dianabol these side effects were on their own. From the urinary system: often – a dose-dependent increase urea levels in blood serum. You may experience hyperuricemia.
Described isolated cases of acute renal failure. For the skin and skin appendages: possible skin manifestations of allergic reactions to pegaspargazu (erythema, rash, pruritus). We describe a case of epidermal necrolysis (Lyell’s syndrome).On the side of the thyroid and parathyroid glands: in some cases, were observed transient and secondary hypothyroidism, decreased thyroxine binding globulin. There have been reports of individual cases of hypoparathyroidism. Other: febrile reactions such as fever, chills (occur in 2-5 hours after administration and are typically dealt with on their own); in rare cases, may increase the temperature to the value of life-threatening. Injection site reactions (including pain, inflammation or congestion), malaise, weight loss, accession secondary infections, sepsis, septic shock.
Antidote for Onkaspara unknown. Anaphylactic reactions require immediate administration of epinephrine, corticosteroids, antihistamines and the use of oxygen.
3 patients received 10 000 IU / m² Onkaspara intravenously. One of them noted a slight increase in serum liver transaminases, another 10 minutes after the start of infusion, a rash, which took place after a slow infusion rate and the appointment of antihistamines. A third patient had no side effects.
The interaction with other drugs and other forms of interaction
Inhibition whey proteins may increase the toxicity of other drugs that bind to the protein.
Also, in the inhibition of protein synthesis and replication cells may influence the action dianabol of drugs such as methotrexate, for pharmaceuticals which require cellular effects replication.
may enhance the toxicity of other drugs affecting the function of the liver. It should be considered when coadministered with drugs that affect blood clotting and platelet aggregation, such as coumarin, heparin, dipyridamole, aspirin or non-steroidal anti-inflammatory drugs.
The use of uricosuric protivopodagricakih drugs may increase the risk of kidney disease associated with increased production of uric acid. During treatment should avoid alcohol.
Introduction should be supervised by a specialist who is experienced in the use of anticancer chemotherapeutic agents.
Hypersensitivity reactions, including life-threatening anaphylaxis, are more common in patients with known hypersensitivity to other forms of L-asparaginase. The risk of hypersensitivity reactions increases with repeated use, however, in rare cases, such reactions may also occur in the first introduction .
Routine rule should monitor the patient for 1 hour after administration of the drug and the availability of affordable resuscitation equipment and drugs for the treatment of anaphylaxis (epinephrine oxygen, glucocorticosteroid drugs, etc.). In case of allergic reactions, injection of the drug should be discontinued immediately and take the necessary remedial measures.
During the chemotherapy using may arise severe toxic liver damage, and nervous system. Dianabol should be used with caution in combination with hepatotoxic agents, especially in the presence of hepatic dysfunction.
For early detection of pancreatitis should be regularly to determine serum levels of amylase. If signs of pancreatitis Onkasparom treatment should be discontinued.
In connection with the risk of hyperglycemia in the treatment necessary to monitor the level of glucose in the blood and urine sugar. In excess blood glucose levels of 10-11 mmol / l shows the use of insulin and conducting infusion therapy. Risk factors for hyperglycemia: age over 10 years, overweight and Down syndrome.
When using Onkaspara together with hepatotoxic drugs requires monitoring of liver function.
Since Onkaspar effect on plasma proteins, it is necessary to monitor fibrinogen, prothrombin time and partial thromboplastin time.
To prevent development of nephropathy associated with increased formation of uric acid as a result of the collapse of a large number of white blood cells, recommended the appointment of allopurinol, increasing fluid intake, alkalizing urine.
Women and men during treatment should use reliable methods of contraception.
in case of accidental contact with skin or mucous membranes must be thorough washing for 15 minutes, water (mucous membranes) or soap and water (skin).
Some side effects may adversely affect the ability to control the car and the performance of potentially hazardous activities that require high concentration and psychomotor speed reactions (especially while receiving alcohol). anabolika.com wachstumshormone kaufen muskelaufbau anabolika