Treatment of mitoxantrone should be carried out under the supervision of a physician dianabol steroids who has experience with anticancer drugs.
In the course of treatment requires systematic monitoring picture peripheral blood (before each administration must be conducted a complete blood count, including platelet count), laboratory parameters of liver function, as well as activities cardiac echocardiography with the definition of left ventricular ejection fraction.
After a total dose of mitoxantrone of 100 mg / m 2 definition LVEF values should always be carried out before each successive administration. Cardiovascular disease in the active or inactive phase, radiation therapy to the mediastinum / pericardial area, previous held or carried out simultaneously with the treatment of mitoxantrone prior treatment with other anthracyclines or anthracenediones and concomitant treatment with other cardiotoxic drugs may increase the risk of toxic damage to the heart. Cardiac risk increases when exceeding a total dose of mitoxantrone of 140 mg / m 2 , however, toxic heart failure may occur at lower cumulative doses of the drug.
Since in some patients with acute leukemia may develop pronounced stomatitis, it is recommended to carry out preventive measures.
When treating leukemia hyperuricemia may occur as a result of the rapid disintegration of the tumor cells. If necessary to assign gipourikemicheskie drugs.
In the case of extravasation must stop administering the drug and if necessary to continue infusion into another vein.
Application of topoisomerase II inhibitors, including mitoxantrone in combination with other anticancer drugs and / or radiotherapy may lead to the development of dianabol steroids acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).
In connection with the immunosuppressive effect of the drug and the possibility of severe infections is not recommended during chemotherapy used live vaccines.
Vaccination should be carried out 3 months after completion of therapy.
Women and men during treatment with mitoxantrone, and and for 6 months after its cancellation should use reliable methods of contraception.
avoid contact with skin or mucous membranes, as may cause tissue necrosis. The skin, in case of contact with the product, wash thoroughly with warm water.
If necessary, undiluted solution Onkotrona (in aseptic fence of the drug from a vial) can be used in part for 7 days when stored at the temperature above 25 ° C.
After dilution, Onkotrona solution should be used within 4 days (aseptic sampling, storage at a temperature of 4-25 ° C), after 96 hours should not be used unused medication.
in the period of treatment must be careful when driving vehicles and occupation of other dianabol steroids potentially hazardous activities that require high concentration and speed of psychomotor reactions. anabolske steroider salg