Orotic acid and its dianabol side effects for men salts are involved in metabolism. Potassium and magnesium, being important intracellular ions play an essential role in the function of many enzymes.
Orotic acid is a precursor of pyrimidine nucleotides making up the nucleic acids, it is also necessary for the synthesis of amino acids; uridine intermediate products in the process of education orotata uratsilmonofosfata stimulates glycolysis, thereby contributing to the synthesis of adenosine triphosphate (ATP).Orotic acid and its salts normalize protein metabolism; enhance tissue repair and regeneration. Orotic acid also has an anabolic effect; It enhances the formation of albumin in the liver during prolonged hypoxia, including with chronic heart failure; It improves the functional condition of the heart. Orotic acid is also required for fixation on magnesium ions and ATP in the cell displays its action.
Magnesium is an essential macronutrient physiological role played by the calcium antagonist activates over 300 biochemical reactions as a cofactor of various enzymes involved in the process of muscle contraction; promotes normal functioning cardiomyocytes; increases the resistance to stress; It enhances the effect of kardiotropnyh, antiarrhythmic and antihypertensive agents. The use of magnesium is indicated for conditions associated with its deficit.
Potassium is the major intracellular ion, is involved in the regulation of the most important functions of the body, has a mild diuretic effect, reduces the arrhythmogenic properties of cardiac glycosides. His administration is also
necessary in case of insufficiency of this ion, including treatment with thiazide diuretics.
The combination of potassium and magnesium orotate to orotate single formulation greatly increases the therapeutic efficacy of each component as orotic acid plays a role retainer magnesium and potassium ions, thus increasing their regulatory functions biochemical and physiological processes.
Coronary heart disease (stable angina), supraventricular arrhythmias (as an additional tool in the complex therapy).
- Hypersensitivity to the drug;
- acute and chronic renal failure, anuria;
- urolithiasis (phosphate and magnesium-calcium calculi);
- atrioventricular block (I-III degree);
- cardiogenic shock;
- metabolic acidosis;
- myasthenia gravis;
- liver cirrhosis with ascites;
- age of 18 years;
- pregnancy and lactation
CarefullyImpaired dianabol side effects for men renal function.
If you have one of these diseases, before taking this medication, you should consult with your doctor.
Application of pregnancy and during breastfeeding
Use of the drug during dianabol side effects for men pregnancy is contraindicated, due to the lack of data on its use during pregnancy. You must stop breast-feeding during the use.
Dosing and Administration
The capsules should be taken orally, with a little water. Apply 4 capsules 3 times a day. The duration of treatment of at least 4-6 weeks. Repeated courses – on doctor’s advice.
Hyperkalemia (nausea, vomiting, diarrhea, paresthesia), gipermagniemiya (facial flushing, thirst, bradycardia, decreased blood pressure, muscle weakness, fatigue, paresis, coma, areflexia, respiratory depression, convulsions), nausea, vomiting, diarrhea, epigastric pain (in patients with anatsidnyh gastritis or cholecystitis), may develop allergic dermatitis. If any of these instructions side effects are compounded, or if you notice any other side effects not mentioned in the instructions, inform your doctor.
Symptoms; hyperkalemia and gipermagniemiya. Treatment: in / calcium chloride; if necessary – hemodialysis and peritoneal dialysis.
Interaction with other drugs
concomitant use of potassium-sparing diuretics (triamterene, spironolactone, amiloride), beta-blockers, cyclosporine, heparin, inhibitors of angiotensin converting enzyme (ACE) inhibitors, non-steroidal anti-inflammatory drugs (NSAIDs) increases the risk of hyperkalemia until the development of arrhythmia and asystole. The use of potassium products in conjunction with corticosteroids eliminates hypokalemia caused by the latter. Under the influence of potassium decreases the unwanted effects of cardiac glycosides. Enhances batmotroponoe negative effects of antiarrhythmic agents. General anesthetics (funds for general anesthesia) enhance the inhibitory effect of magnesium drugs on the central nervous system; while the use of depolarizing muscle relaxant (atracurium besylate; decamethonium bromide; suxamethonium chloride, bromide, iodide) may increase neuromuscular blockade; calcitriol increases the magnesium content in blood plasma, calcium magnesium drugs reduce the effect of drugs.
Pharmacokinetic: knitting and enveloping means reduce the absorption of the drug in the gastrointestinal tract and the need to comply with the three-hour interval between doses of the drug with the listed facilities. When applied simultaneously with iron preparations, tetracycline and sodium fluoride removals decreased in the gastrointestinal tract.
When applied simultaneously with iron preparations, tetracycline and sodium fluoride receiving the drug should be delayed for at least 2 hours.
In an application with drugs potassium is recommended to control the content of potassium in the blood plasma.
If you have any signs of diarrhea, the dose should be reduced.
In some cases, medication for allergic dermatoses cancel, antihistamines are used as needed. Clinical studies on the effects on the ability to drive vehicles and particular activities that require high concentration and speed of psychomotor dianabol side effects for men reactions, have been conducted.
10 capsules or 15 capsules in blisters of PVC film and aluminum foil printed patent. Bank or 6 contour cell packs of 10 capsules or 4 contour cell packages of 15 capsules with instructions for use are placed in a pile of cardboard.